Visfatin/NAMPT in osteoarthritis: a pro-inflammatory adipokine involved in synovium-cartilage and synovium-bone communications
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چکیده
منابع مشابه
Obesity-associated metabolic syndrome spontaneously induces infiltration of pro-inflammatory macrophage in synovium and promotes osteoarthritis
OBJECTIVES Epidemiological and experimental studies have established obesity to be an important risk factor for osteoarthritis (OA), however, the mechanisms underlying this link remains largely unknown. Here, we studied local inflammatory responses in metabolic-OA. METHODS Wistar rats were fed with control diet (CD) and high-carbohydrate, high-fat diet (HCHF) for period of 8 and 16 weeks. Aft...
متن کاملPro-inflammatory cytokine expression in synovium, synovial fluid, and articular cartilage of naturally osteoarthritic equine ca
Introduction: Many cytokines including tumor necrosis factor alpha (TNFα) and interleukin one beta (IL-1β) are increased in osteoarthritic joints. They bind at different receptors but cause a similar increase in NFκB and JNK. These intermediates then increase the transcription of matrix metalloproteinases, cycloxygenase-2, and inducible nitric oxide synthase. The end result is increased cartila...
متن کاملS100A8/A9 increases the mobilization of pro-inflammatory Ly6C monocytes to the synovium during experimental osteoarthritis
Background: Monocytes are dominant cells present within the inflamed synovium during osteoarthritis (OA). In mice, two functionally distinct monocyte subsets are described: pro-inflammatory Ly6C and patrolling Ly6C monocytes. Alarmins S100A8/A9 locally released by the synovium during inflammatory OA for prolonged periods may be dominant proteins involved in stimulating recruitment of Ly6C monoc...
متن کاملS100A8/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis
BACKGROUND Monocytes are dominant cells present within the inflamed synovium during osteoarthritis (OA). In mice, two functionally distinct monocyte subsets are described: pro-inflammatory Ly6Chigh and patrolling Ly6Clow monocytes. Alarmins S100A8/A9 locally released by the synovium during inflammatory OA for prolonged periods may be dominant proteins involved in stimulating recruitment of Ly6C...
متن کاملSynovium in the pathophysiology of osteoarthritis
Osteoarthritis Osteoarthritis (OA) is the most common form of arthritis and is among the most prevalent chronic human health disorders in an aging population. It is estimated that over 50% of people aged 65 years and older show radiological signs of OA [1]. This disease mostly affects the hands, hips, knees and spine. The risk factors associated with OA pathophysiology include development-, met...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2013
ISSN: 1063-4584
DOI: 10.1016/j.joca.2013.02.054